To suppress pro-inflammatory cytokines L.delbrueckii and L.rhamnosus inhibit NF-B and MAPK signaling pathways, reducing levels of TNF-, IL-6, and IFN- production (146, 147)
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The conversion of vitamin B 6 to its active coenzyme form in tissues, pyridoxal 5'-phosphate (PLP), requires the FMN-dependent enzyme, pyridoxine 5'-phosphate oxidase (PPO) (7)