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10.1128/MCB.01421-12 [DOI] [PMC free article] [PubMed] [Google Scholar] Li Y, Que M, Wang X et al (2023a) Exploring astrocyte-mediated mechanisms in sleep disorders and comorbidity

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Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis

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