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Am J Physiol Endocrinol M 2009;296:E829E41

Baseline glucose and oxygen concentrations remained stable across groups, but IGF-1 LR3 treatment significantly reduced circulating amino acids, particularly branched-chain amino acids

Nonetheless, when reduced to the nanoscale, these materials may interact with biological systems in novel ways, and our understanding of their long-term toxicological profile is incomplete (198, 199)