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In contrast, the HF-SAAR diet led to a markedly increased in liver PHGDH (5-fold) and PSAT1 (70-fold) protein expression (Fig

This constitutive abundance combined with injury-site concentration creates a research context in which exogenous TB-500 is supplementing and amplifying an endogenous repair biology rather than introducing a foreign signal a distinction with implications for how TB-500s research findings are interpreted in the context of endogenous tissue repair mechanisms