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Finally, a study of Parkinsons patients found that combining 1g of daily omega-3 with 400 IU of vitamin E for three months led to an increase in glutathione concentrations, total antioxidant capacity and a reduction in inflammatory C-reactive protein

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Conversely high doses, and/or inadequate removal of ROS caused by several mechanisms, i.e., ionizing radiation, bioactivation of xenobiotics, inflammatory processes, increased cellular metabolism, activation of oxidases, and oxygenases, can be very dangerous, modifying susceptible molecules including DNA, lipids, and proteins