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dose 1.8 mg/day) reported improvement in satiety [23]

Evidence from two large, international phase 3 clinical trials, published in The Lancet Diabetes & Endocrinology , indicates that this higher dose may provide an important treatment alternative for people who have not achieved sufficient results with current therapies

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This approach aligns with clinical evidence showing that slower dose escalation produces fewer dropouts due to intolerance

27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity