In addition to promoting weight loss, activating POMC anorexigenic neurons, and increasing leptin sensitivity, liraglutide reduced gliosis and increased expression of the anti-apoptotic gene Bcl2
Semaglutide and its newer cousin tirzepatide have thus been dubbed game changers for obesity
patent for semaglutide expires March 20, 2026, but other patents may extend exclusivity until December 5, 2031
Yes, some pigmentation changes are linked to nutritional deficiencies (like B12) or hormonal/stress-related factors, though these are less common causes
Be skeptical of high absorption hype: formulations like dihydroberberine and berberine phytosome have small human pharmacokinetic studies showing higher blood levels than standard berberine, but that does not automatically mean better real-world weight loss