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In addition, VPA may induce encephalopathy, mainly manifested as acute or subacute encephalopathy, and is associated with hyperammonemia, L-carnitine deficiency and urea, circulating enzyme dysfunction (Wu et al., 2021)

these effects are reversed when it is removed

Managing GI side effects and titration strategies Gastrointestinal adverse events affect 40-70% of treated patients [25], primarily consisting of: Nausea (15-50%) Diarrhea (5-25%) Vomiting (5-10%) Slow titration remains fundamental to mitigating these effects

Specifically, low levels of adiponectin in serum serve as an independent biomarker for CAD severity and future atherosclerotic CVD events [59]