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Advanced analytical techniques are enabling researchers to track the compound's effects on global metabolite profiles, revealing complex interactions between NAD+ metabolism, methylation cycles, and other metabolic pathways that were previously unappreciated

Severe or worsening xerostomia may indicate an underlying condition requiring investigation, such as Sjgren's syndrome, uncontrolled diabetes, or medication interactions that need addressing

Not sure that any actual weight loss has happened yet

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Protein malnutrition, though less common, may occur in patients with severe appetite suppression or food aversions, potentially compromising muscle health and function over time