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When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

Older people who struggle to absorb B12

Learn our suggested B12 dosage and frequency

If used in these patients, more frequent monitoring is required because of the potential for erratic or blunted absorption