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5 The primary players found in the endometriotic milieu are interleukin-2 (IL-2), interleukin-8 (IL-8), interleukin 10 (IL-10), interleukin-27 (IL-27), interleukin-1 (IL-1), interferon (IFN-), tumor necrosis factor (TNF-), cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2)