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In another work, the combination of cyclodextrin (CDs) with agar to render chemically cross-linked hydrogels with drugs by the formation of inclusion complexes or ionic bonds with polysaccharide enhanced loading ability, dually controlled delivery, release profile based on CD affinity and tunable external stimuli such as pH and ionic strength [171]

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This direct administration ensures a higher concentration of B12 reaches the cells, maximizing its effectiveness in restoring optimal B12 levels

These features may suggest complications or alternative diagnoses requiring investigation