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For example, VSG surgery enhances resting-state functional connectivity between the hippocampus and the insula [41] and between the dorsolateral PFC and the anterior cingulate, with these outcomes accompanied by dampened cravings for high calorie foods [42] and reduced fasting levels of ghrelin [41,42]

This process was mechanistically linked to enhanced DNA damage and the accumulation of dsDNA, which triggered the activation of cGAS-STING signaling

There are a couple of reasons this can happen

10.1186/1471-2091-13-23 58 LeeT

Apolipoprotein B48 (apoB48) is the primary structural component of the triglyceride (TG)-rich chylomicrons (CMs) secreted by the intestine, and excess apoB48 secretion has been associated with the formation of atherosclerotic plaques (2)