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That approval status is a hard regulatory fact, and it is the single biggest reason a CagriSema-versus-tirzepatide comparison is not a comparison of equals: one product has cleared a full regulatory efficacy-and-safety review, and the other has not yet

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However, oral supplementation may be limited by: Gastrointestinal intolerance Malabsorption syndromes Nausea or reduced appetite Medication-related absorption changes IV B-complex: Bypasses gastrointestinal absorption Allows predictable uptake Can be combined with hydration and other supportive nutrients May be considered when oral options are ineffective or poorly tolerated When B-Complex IV Therapy May Be Appropriate B-complex IV therapy is not intended for routine or indefinite use