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10.1186/1742-4682-5-8 35 RefsumH.YajnikC

Blood glucose self-monitoring is necessary to adjust the dose of sulfonylurea and insulin particularly when Semazic is started and insulin is reduced

It says the majority of that early drop represents water and glycogen rather than adipose tissue, and lists four contributors: reduced caloric intake from appetite suppression, decreased water retention as insulin levels normalize, slowed gastric emptying, and minor glycogen depletion

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Clinical trials reveal up to 20.9% body weight loss, making it the most effective among weight loss medications currently on the market