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Biological evaluation demonstrated that compound 37 possesses the most potent inhibitory activity, with an IC 50 of 8 nM (Figure 5)

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Results Of the nine subjects (five men, four women), five subjects (three men, two women) were included in the tirzepatide 5 mg group, one subject (one man) was included in the tirzepatide 10 mg group, two subjects (two women) were included in the tirzepatide 15 mg group, and one subject (one man) was included in the dulaglutide 0.75 mg group (Table 1)

At the same time, people with psychiatric disorders are more likely to develop metabolic conditions such as obesity and diabetes

These results are shown graphically in Fig