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32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier

Interestingly, whole-body, or CNS-specific, GLP-1R knockout in a mouse did not result in sizable change in body weight, fat mass or hyperphagia

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Acetyl-CoA carboxylase (ACC), which is the enzyme that carboxylates acetyl-CoA in the first, committed step of DNL is under the control of TH with T3 increasing A cc transcription