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Through enhanced pharmacokinetic profiles, once-weekly GLP-1RA injections, notably semaglutide, are becoming increasingly popular in the treatment of T2DM

In aged C57BL/6J models, CJC-1295 non-DAC at 10 g/kg 3/week for 8 weeks produces IGF-1 elevation from 88 8 to 168 14 ng/mL (+91%), skeletal muscle protein synthesis +2228% (puromycin incorporation), and BV/TV improvement from 8.4% to 12.4% (CT)

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Drugs that exhibited statistically insignificant differences compared to the 0 Gy control (hits) with the glutathione assay were then tested with the senescence assay to discover library members that were efficacious in both assays (double hits)

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