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Both potassium antimonial tartrate and oltipraz inhibit TGR 18 by a covalent mechanism and were used clinically for schistosomiasis treatment but were discontinued due to unacceptable side effects 28,29

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However, mechanistic data are very limited, and definitive conclusions regarding their contribution to MASH cannot yet be established

To assess whether pharmacological inhibition of Ire1 can also alleviate IRI, we treated wild-type C57BL6 mice with vehicle, 48c, or liproxstatin-1 (a ferroptosis inhibitor used as a positive control for reducing IRI Ref