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Itching during GLP-1 therapy usually results from dehydration (reduced fluid intake due to nausea), rapid fat mobilization triggering inflammatory responses, or changes in diet and skin flora

As the first FDA-approved dual incretin receptor agonist, tirzepatide serves as a key reference compound for GIP/GLP-1 synergy research and a benchmark for emerging triple agonist compounds including retatrutide

However, the absence of joint pain from a common side-effect list does not mean that no one will experience it

and also to encourage the improvement of processes to ensure that we are all better protected

Tirzepatide was also associated with a significantly lower risk of all-cause mortality compared with dulaglutide [7]