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But GABA can also be oxidatively synthesized from Put, by either acetylation and subsequent oxidation by monoamine oxidase (seen more often in glia), or oxidation by diamine oxidase and subsequent dehydrogenation (seen more often in neurons) (Figure 1

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The FLINT trial on obeticholic acid in NASH patients, as elaborated earlier, emphasized the need for FXR agonists with better efficacy, safety and tolerability profiles