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In rare cases, certain metabolic imbalances can cause glutathione to accumulate rather than being used

For instance, a minimum intracellular selenium status (in terms of the concentration of hydrogen selenide) is required for the translation of all seleno-GPxs

Mitochondrial glutathione depletion is directly linked to oxidative damage to mitochondrial DNA, impaired cellular energy production, and the patterns of age-related functional decline observed across tissues

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