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Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)

These figures are provided for informational and research reference purposes only and do not constitute dosing advice for humans

One target of PMad, Daughter against dpp (Dad), can regulate Dpp signalling activity via negative feedback 28,29,30

Storage: Store below 25C (Air Conditioning) and protect from light