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Melatonin Mitigated Histological Alterations in the DRG Within the FM-like Model Normal control samples exhibited intact neuronal types of various sizes with preserved subcellular details (black arrow), few sporadic degenerated neurons, well-organized satellite ganglionic cells (yellow arrowhead), and Schwann cells with intact myelinated nerve fibers

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Additionally, semaglutide demonstrated neuroprotective benefits to the CNS leading to enhancement to cell survival, decreased M1-like microglia numbers, and reduced interleukin-6 and TNF- levels in different brain areas in obesity (Tamayo-Trujillo et al

Theres a lot to be known still