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Physical examination includes vital signs assessment for hemodynamic stability, abdominal examination for tenderness or masses, and digital rectal examination to identify anorectal pathology and characterize stool appearance

Graphical representations of epidermal thickness and neutrophil frequency are presented (Figure 2g and h)

Tolerability varies between individuals and treatment options

However, its angiogenic properties raise legitimate safety considerations, suggesting that indication-specific developmentfavoring acute or localized applicationsmay be more appropriate than chronic systemic exposure

But for some, the effect can become too strong, leading to symptoms that resemble gastroparesis