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Pharmacodynamics : General : In patients with type 2 diabetes, administration of JANUVIA led to inhibition of DPP-4 enzyme activity for a 24-hour period

This is due to the documented capability of Semaglutide to cause inflammation of the pancreas, a severe condition that can lead to a range of complications, including death

DPP-4 inhibition leads to decreased pancreatic inflammatory profile and increased frequency of regulatory T cells in experimental type 1 diabetes

WO2017114191, CN 103848910, CN 104356224, CN 108203462 and CN 108059666 also discloses the process for the preparation of Semaglutide

Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, et al