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Body Mass Index The mean change from baseline to week 68 in BMI was reported as a supportive secondary outcome in the STEP 1 to STEP 4 studies, and thus was not part of the statistical hierarchy (Table 26)

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There was no difference in the anti-inflammatory effect of GLP-1RA between Glp1r Tie2+/+ and Glp1r Tie2-/- mice, indicating that this activity was not dependent on the blood system or endothelial cells

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+++ represent significance compared to other positive drug (++)