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Additionally, HMGB1 promotes endothelial cell proliferation and the release of angiogenic factors such as VEGF, thereby facilitating the implantation and survival of ectopic endometrial cells (Shimizu et al., 2017)

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255 Preclinical and clinical evidence suggests capsaicin can improve lipid and glucose metabolism, support weight loss, and lower the risk of both type 2 diabetes and cardiovascular disease