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doi: 10.1007/s00702-005-0448-4

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This antitumor effect was associated with a shift toward an immunostimulatory tumor-associated macrophage (TAM) phenotype and an enhanced effector T cell response within the tumor microenvironment, mediated by activation of the type I Interferon pathway (238)

Regulatory authorities control the safety, efficacy, and manufacturing processes of the approved drugs