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Children and newborns should also not take it, and people on any prescription medicationsparticularly those on beta-blockers, antidepressants, and immunosuppressantsshould consult with a doctor before adding berberine into their system

van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, et al

Diet-induced obese animals exhibit indices of altered central monoaminergic neurotransmission, including reduced hypothalamic 1 adrenoceptor binding, enhanced electrophysiological responsiveness to norepinephrine application, decreased basal hypothalamic serotonin and dopamine levels, and reduced mesolimbic dopamine activity

Errors in solvent choice, injection technique, or dilution volume directly affect potency, shelf life, and dosing accuracy