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Enclomiphene 25mg raised baseline testosterone (n 32 average 209.8 ng/dL to 405.8 ng/dL) compared to placebo (n=26, average 213.7 ng/dL to 198.5 ng/dL) and was comparable to topical 1% testosterone (n=30, average 210 ng/dL to 462.6 ng/dL)

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Given the reduced lipid peroxidation, improved antioxidant status, and reduced DNA damage in curcumin pretreated groups, the authors concluded that curcumin may induce the transcriptional factors for oxidative stress-related gene expression [23]

Stages of knee OA progression include: Early stage , marked by cartilage softening, bone marrow lesions and mild synovits