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Oxidative stress occurs when the formation of free radicals proliferates beyond what the bodys antioxidant defenses can handle

A major translational hurdle is the development of agents that can effectively cross the BBB to reach central auditory structures

The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer