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An important advantage of SLNs is that they are made from physiological, biodegradable lipids (e.g., triglycerides and fatty acids), many of which are Generally Recognized as Safe (GRAS) for food use (41, 42)

Epoxy fatty acids derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)including 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) and 19,20-epoxydocosapentaenoic acid (19,20-EpDPE)are synthesized via the cytochrome P450 epoxygenase pathway

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Obesity and visceral adiposity are key drivers of HFpEF development and progression, and this may be even more amplified in women, who represent the majority of people with the disease, and bear a heavier burden of symptoms and physical limitations due to HFpEF