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Participants experienced similar side effects to CagriSema, with nausea being the most common

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In one trial, 16 people placed on experimental bed rest for 3 weeks (in order to increase urinary calcium excretion by causing bone breakdown) and treated with 20 mg per day of the bisphosphonate alendronate had lower urine calcium concentrations, and lower calcium oxalate and calcium phosphate saturations, compared with placebo (Ruml 1995)

Pharmacologic inhibition of glycolysis (2-deoxy-D-glucose or oxamate) reduced global lactylation and restored lenalidomide sensitivity, supporting a lactate-fueled resistance mechanism

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