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Mounting evidence suggests that ferroptosis liabilities are frequently imposed by the tumor microenvironment, metastatic niche and nutrient availability, implying that conventional in vitro models may underestimate therapeutic opportunities

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In addition, a significant reduction in kidney volume and hyperfiltration was noted after a three-month treatment in T1DM patients treated with octreotide, a somatostatin analog, compared to placebo-treated patients [212]

Initial concerns regarding pancreatitis and gastrointestinal side effects have been mitigated through extensive clinical trials, which indicate a generally favorable risk-benefit ratio