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Excessive reactive oxygen species (ROS) cannot be promptly eliminated, leading to a series of pathological reactions

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Sepiapterin reductase is encoded by the SPR gene which is located on chromosome 2p13.2 and is composed of 3 exons that encode a 261 amino acid protein

Glutathione STransferases Control Astrocyte Activation and Neuronal Health During Neuroinflammation. Frontiers in Molecular Biosciences 9: 1080140

Research has identified CHAC1 as a direct target of the FOXG1 and TLE1 transcriptional repression complex, which reduces CHAC1 expression in glioblastoma (GBM)