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Research has examined NNMT inhibition as a potential intervention point in metabolic biology, with particular interest in adipose tissue, where NNMT expression is elevated in some obesity models

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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks