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Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD

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Extensive research has revealed that animal models with severe mitochondrial OXPHOS deficiencies consistently exhibit significantly shortened lifespans (Barends et al

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Treated animals showed delayed onset of age-related pathologies, better preservation of organ function, maintained reproductive capacity, reduced tumor incidence, and improved healthspan