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The peptides versus TRT comparison breaks down when each approach makes more sense

4 However, direct evidence that EGT enhances mitochondrial respiration in humans is currently lacking, and available animal data primarily indicate cytoprotection under exercise-induced stress rather than a confirmed primary role as an energy production modulator

Mechanistic interpretations in these studies typically rely on indirect evidence, such as changes in protein markers (e.g., Bax/Bcl-2 ratio, caspase activity), while direct causal validationthrough gene silencing, overexpression, or target binding assaysis rare (Xu G