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17,123 The phenotype of the disease represents the observable characteristics of the disease or patient (such as obstructive sleep apnea in the elderly, men, or Black patients), whereas the endotype refers to the underlying biological mechanisms which drive disease (such as fat distribution, hyporesponsive muscles of the airway, or abnormal craniofacial structures)

Research has investigated its role in sleep-wake cycle regulation, pituitary hormone secretion, stress adaptation, and nociceptive pathways

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Davies, Michael J

GABA and glutamate levels were significantly lower in the hippocampus when compared to a healthy control group