KPV keeps some of that receptor activity, though research in colitis models found its benefit was at least partly independent of MC1R (Kannengiesser et al., 2008)
"Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms", Integrative Medicine: A Clinician's Journal (Encinitas)
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However it is advisable to deliver Vit B12 dose by a deep Intramuscular injection in gluteal or deltoid muscle Alternatively, you can also use oral Vitamin 12 tablets available at most health food stores and pharmacies