Stable gastric pentadecapeptide BPC 157 may recover brain-gut axis and gut-brain axis function
This anatomical advantage creates several benefits: Absorption Rate : 60-80% typical bioavailability [2] Key Advantages : Direct absorption through nasal mucosa bypasses first-pass metabolism Rich blood supply enables rapid systemic distribution Avoids degradation by digestive enzymes Creates almost immediate plasma concentration elevation The nasal cavity's permeable epithelium allows peptides to cross directly into capillaries, then travel to the heart and throughout the body
Acknowledgements This work was supported by National Research Foundation grants [2021R1A5A2021614, 2021R1A2C1005513, and 2022M3A9G8095334] funded by the Ministry of Science and ICT of Korea
In vivo, SLU-PP-332 increases oxidative fiber markers (for example, type IIa), cytochrome-c content, mitochondrial DNA abundance, and expression of OXPHOS genes
Pearson Correlation coefficient (r) was used to measure the linear relationship between two quantitative variables