retatrutide que es Retatrutide—A Game Changer in Obesity Pharmacotherapy Retatrutida y cirugía de contorno:

And how do they cause weight loss

To overcome the selectivity issues of native lysine reactivity, researchers have developed genetic code expansion technologies to introduce non-natural lysine derivatives (such as lysine analogs bearing azide, alkyne, or tetrazine groups) at specific sites in proteins

Parker, B

In diabetes-related AD, GLP-1 promotes mitochondrial biogenesis and the antioxidant system by regulating the PGC-1a signaling pathway in vivo to directly reverse tau hyperphosphorylation.46 GLP-1(9-36) (amide) reduced elevated levels of mitochondrial-derived ROS in the hippocampus of AD model (APP/PS1) mice.47 Exendin-4 significantly increased amyloid protein (A)-induced reduction in mitochondrial function, integrity, respiratory control rate, and mitochondrial P/O ratio in all brain regions and decreased A-induced increase in the mitochondrial complex enzyme-I, IV, and V activities in all brain regions.36 Exenatide also improved hippocampal mitochondrial morphology and dynamics and reduced oxidative stress in the hippocampus of AD model (5xFAD) mice.48 The mechanism by which GLP-1 RA regulates mitochondrial function and oxidative stress has not been well elucidated

Adding glucagon activation to the GLP-1/GIP combination is what pushes retatrutide to the 24% to 29% weight loss range