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Here is a general timeline of what many patients report: It is worth repeating that these results do not happen in a vacuum

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We also noted a slightly greater retention of C-capsids in the nucleus (twofold increase in DDX3X depleted cells) that also suggested a possible role for DDX3X in nuclear capsid budding, although this did not reach statistical significance

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Due to technical limitations (the lack of cell lines with sufficient expression of the mutants), we were unable to individually assess the roles of K301 and R365 in splicing and proliferation