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Three-week old, female Swiss-Webster mice obtained from the Charles River were housed in the Comparative Research Center of Rush University Medical Center

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Glutathione is one of the most powerful intracellular (within the cell) defence nutrients found in almost every cell in the body and is highly active, particularly in cells that are most susceptible to toxicity such as the brain, kidneys, liver, heart, lungs, skin, intestinal epithelia, cornea and retina 2

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining