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Dehydration from gastrointestinal side effects such as nausea, vomiting, or diarrhea can lower blood volume and blood pressure, leading to lightheadedness when standing or moving quickly

(2022, July 21)

There is no clinical oversight to manage adverse reactions if they occur

In the only direct evaluation of brain insulin resistance in PD, insulin signaling abnormalities were identified in the dorsolateral prefrontal and posterior parietal cortex of those with cognitive impairment, but not in those who were cognitively normal [72]