In the published literature, acetaminophen has been reported to be clastogenic when administered at 1500 mg/kg/day to the rat model (3.6-times the MHDD, based on a body surface area comparison)
Siemes H, Nau H, Schultze K, Wittfoht W, Drews E, Penzien J, Seidel U: Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity
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Alcohol consumption with this drug can lead to further complications such as pancreatitis
In line with these results, we detected lower CI activity in total lysates of Gclc -deficient FoB compared to control FoB (Fig