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Philos Trans R Soc Lond B Biol Sci

The production and secretion of thyroid hormones into the blood starts as early as the 10 th - 12 th week of gestation ( In children, acquired hypothyroidism is caused primarily by autoimmune thyroiditis with a current prevalence of 12% among children and adolescents ( Thyroid cancers are less common in children than in adults, but it has been estimated that 1.8% of thyroid malignancies diagnosed in the US are in people aged less than 20 years

Refrigeration slows this conversion, maintaining effective preservative concentration closer to the 0.9% starting level through the 28-day window