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Both primary papers on mouse embryos lacking TrxR1 reported that it proved impossible to establish cultures of primary fibroblasts from mutant embryos

Schrade et al., 2022)

Important safety considerations include risk of pancreatitis (stop treatment and seek urgent care if severe persistent abdominal pain radiating to the back occurs), gallbladder disease , diabetic retinopathy complications (especially with rapid improvement in blood glucose control), and risk of acute kidney injury with dehydration

Longitudinal studies of up to eight years post-surgery have demonstrated sustained improvements in size, swelling, pain, heaviness, function and quality of life