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Fertility and Sterility , 86(6), 1561-1572

Therefore, the results of the studies on fish suggest that riboflavin deficiency decreases the antioxidant enzymes mRNA level through, at least in part, the down-regulation of NRF2 gene expression, up-regulation of Keap1 and down-regulation of CK2, resulting in the prevention of NRF2 nuclear translocation and activation (Fig